Retatrutide
Also known as: LY3437943
- CAS Number
- 2381089-83-2
- Molecular Formula
- C221H342N46O68
- Molecular Weight
- 4731.4 g/mol
- Purity
- Batch-specific
- Form
- Lyophilized powder
- Enquiry Sizes
- 5 mg • 10 mg • Bulk API (gram+)
- Peptide Sequence
- Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-αMeLeu-Leu-Asp-Lys-Lys-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (Aib at positions 2 and 20; α-methyl-Leu at position 13; Lys17 side chain lipidated via γGlu-AEEA linker to a C20 fatty-diacid; C-terminal amide)
Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.
Configure Your Request
Documentation requests are reviewed against the records available for the applicable lot. Availability, methods, and values must be confirmed for the specific enquiry and are not promised in advance.
Form supplied: Lyophilized powder. Your selections are carried into the quote request automatically.
Overview
Retatrutide is a synthetic peptide engineered to activate three metabolic receptors simultaneously: the GIP receptor, the GLP-1 receptor, and the glucagon receptor. This "triple agonist" pharmacology places it at the frontier of incretin research, where investigators examine how combined receptor engagement shapes energy expenditure, glucose control, and adiposity in preclinical models.
The addition of glucagon receptor activity distinguishes retatrutide from dual agonists: glucagon signaling has been studied in relation to hepatic lipid metabolism and energy expenditure in preclinical models, making the molecule a key tool for dissecting the contribution of each receptor axis. These are preclinical observations that do not establish clinical efficacy.
BioTech Pharma supplies retatrutide as a lyophilized powder for laboratory research use only. Lot-specific analytical documentation may be available and should be confirmed for the applicable material. Availability and commercial terms, including bulk quantities, are confirmed per enquiry.
Research Applications
- Triple-agonist (GIP/GLP-1/glucagon) receptor pharmacology
- Energy-expenditure and thermogenesis models
- Hepatic lipid metabolism research
- Comparative studies against single- and dual-agonist peptides
- Obesity-model pharmacodynamics
Frequently Asked Questions
Scientific References
Analytical Data
Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:
- HPLC purity result
- LC-MS identity confirmation
- Appearance
- Net content
Request the records you need with your quote and we will confirm availability for your batch.
Procurement Details
Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.
Storage & Handling
Lyophilized: store at −20 °C, protected from light. Reconstituted: keep at 2–8 °C and determine working-solution stability empirically per lot, as reconstituted stability varies with diluent, concentration, and handling.
Related Compounds
Tirzepatide
Dual GIP/GLP-1 receptor agonist peptide studied in incretin-pathway and metabolic research, supplied as a lyophilized powder.
Semaglutide
The reference GLP-1 receptor agonist analog — a cornerstone compound for incretin-pathway and appetite-regulation research.
MOTS-C
Mitochondrial-derived 16-amino-acid peptide at the center of exercise-mimetic, AMPK, and metabolic-homeostasis research.