2D Molecular Structure
- CID
- 146675088
- Standard InChIKey
- WYTHCOXVWRKRAH-LOKRTKBUSA-N
- Residue Count
- 16 AA
- Structural Modifications
- Mitochondrial-derived peptide (12S rRNA ORF)
- Contains two methionines (oxidation-sensitive); free N- and C-termini
MOTS-C
Also known as: Mitochondrial ORF of the twelve S c peptide
- CAS Number
- 1627580-64-6
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2174.6 g/mol
- Purity
- Batch-specific
- Form
- Lyophilized powder
- Enquiry Sizes
- 10 mg • Bulk (gram+)
- Peptide Sequence16 residues
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.
Configure Your Request
Documentation requests are reviewed against the records available for the applicable lot. Availability, methods, and values must be confirmed for the specific enquiry and are not promised in advance.
Form supplied: Lyophilized powder. Your selections are carried into the quote request automatically.
Overview
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of the founding members of the mitochondrial-derived peptide (MDP) class discovered in 2015. Its existence reframed the mitochondrial genome as a source of signaling peptides, not just respiratory-chain subunits.
Preclinical research has studied MOTS-c as a mitochondrial-to-nuclear signaling molecule: it translocates to the nucleus under metabolic stress and modulates gene expression through AMPK and NRF2-linked pathways in laboratory models. These are preclinical observations that do not establish clinical efficacy. Studies span exercise physiology, insulin-sensitivity models, and age-related metabolic decline.
Because the sequence contains two methionines, handling that limits oxidative exposure is advisable. BioTech Pharma supplies MOTS-c as a lyophilized powder for laboratory research use only; lot-specific analytical documentation may be available and should be confirmed for the applicable material.
Research Applications
- Mitochondrial-derived peptide (MDP) biology
- AMPK pathway activation studies
- Exercise-mimetic and muscle-metabolism research
- Insulin-sensitivity models
- Mitochondrial-nuclear communication research
Frequently Asked Questions
Scientific References
Analytical Data
Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:
- HPLC purity result
- LC-MS identity confirmation
- Appearance
- Net content
Request the records you need with your quote and we will confirm availability for your batch.
Procurement Details
Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.
Storage & Handling
Lyophilized: store at −20 °C, protected from light. Reconstituted: keep at 2–8 °C and determine working-solution stability empirically per lot, as reconstituted stability varies with diluent, concentration, and handling.
Related Compounds
NAD+
The universal redox coenzyme — foundational to cellular-energy, sirtuin, and aging-biology research.
Epithalon
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on pineal epithalamin, studied in telomerase and aging-biology research.
Bacteriostatic Water
Aqueous laboratory research reagent studied as a companion diluent for reconstituting lyophilized peptides in the laboratory.