IGF-1 LR3
Also known as: Long R3 IGF-1, Long-(Arg3)-IGF-1, LR3-IGF-1
- CAS Number
- 143045-27-6
- Molecular Formula
- C400H625N111O115S9
- Molecular Weight
- ≈ 9117.6 g/mol
- Purity
- Batch-specific
- Form
- Lyophilized powder
- Enquiry Sizes
- Research vial • Bulk / custom fill (quote required)
- Peptide Sequence
- Met-Phe-Pro-Ala-Met-Pro-Leu-Leu-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala (83 residues: 13-aa N-terminal extension MFPAMPLLSLFVN + human IGF-1 with Arg substituted for Glu at position 3; three native IGF-1 disulfides)
Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.
Configure Your Request
Documentation requests are reviewed against the records available for the applicable lot. Availability, methods, and values must be confirmed for the specific enquiry and are not promised in advance.
Form supplied: Lyophilized powder. Your selections are carried into the quote request automatically.
Overview
IGF-1 LR3 (Long R3 IGF-1) is a synthetic 83-amino-acid analogue of human insulin-like growth factor 1. It differs from native IGF-1 (70 residues) by a 13-residue N-terminal extension (MFPAMPLLSLFVN) and by an arginine substituted for glutamic acid at position 3. These changes preserve agonist activity at the IGF-1 receptor while markedly lowering affinity for IGF-binding proteins, so a larger free fraction is available in binding-protein-rich media.
That property makes IGF-1 LR3 a widely used supplement in cell-culture research, where it sustains IGF-1-receptor signaling in the presence of serum binding proteins more effectively than the native protein. Investigators use it to study proliferation, differentiation, and IGF-axis signaling pathways in vitro. Any effects observed in cell or animal models are preclinical and should be distinguished from established human IGF pharmacology.
BioTech Pharma supplies IGF-1 LR3 as a lyophilized powder for laboratory research use only. It is a folded, disulfide-containing protein; lot-specific analytical documentation may be available and should be confirmed for the applicable material. Bulk or custom-fill quantities are available by quote.
Research Applications
- IGF-1 receptor signaling studies
- Cell-culture growth-factor supplementation
- IGF-binding-protein interaction research
- Proliferation and differentiation assays
- Recombinant/analogue protein folding and disulfide chemistry
Frequently Asked Questions
Scientific References
Analytical Data
Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:
- HPLC purity result
- LC-MS identity confirmation
- Appearance
- Net content
Request the records you need with your quote and we will confirm availability for your batch.
Procurement Details
Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.
Storage & Handling
Lyophilized: store desiccated at −20 °C, protected from light. Reconstituted: keep at 2–8 °C and establish working-solution stability empirically per lot; as a disulfide-bonded protein it is sensitive to freeze–thaw cycling and reducing conditions, so aliquot prepared solutions.
Related Compounds
Tesamorelin
Stabilized GHRH analog used in growth-hormone-axis research, engineered for resistance to enzymatic degradation.
CJC-1295 with DAC
Long-acting GHRH analogue bearing a maleimidopropionyl-lysine drug-affinity complex that binds albumin, studied in GH-axis research.
Ipamorelin
Selective pentapeptide ghrelin-receptor agonist prized in GH-axis research for its clean receptor-selectivity profile.