What does the DAC in CJC-1295 do?

DAC (drug affinity complex) is an Nε-maleimidopropionyl group on a terminal lysine that reacts with a free thiol on serum albumin, tethering the peptide to albumin and greatly extending its circulating half-life in research models.

How is CJC-1295 with DAC different from the no-DAC version?

The no-DAC form (Modified GRF(1-29)) shares the same tetrasubstituted GRF(1-29) backbone but lacks the position-30 maleimidopropionyl-lysine, so it does not tether to albumin and is much shorter-acting. The two are frequently conflated in the literature but are distinct molecules.

Home CatalogCJC-1295 with DAC

2D Molecular Structure

CID: 91971820
Standard InChIKey: ZUQGTWKGESAQCD-ZGFIGYLBSA-N
FDA UNII: 62RC32V9N7
Residue Count: 30 AA
Structural Modifications: C-terminal amide (–NH2)
Nε-maleimidopropionyl (DAC) on C-terminal Lys30 — free maleimide, pre-albumin-conjugation form
No disulfide

endocrine Research

CJC-1295 with DAC

Also known as: CJC-1295 DAC, DAC:GRF, drug affinity complex:GRF

Long-acting GHRH analogue bearing a maleimidopropionyl-lysine drug-affinity complex that binds albumin, studied in GH-axis research.

CAS Number: 446262-90-4
Molecular Formula: C165H269N47O46
Molecular Weight: ≈ 3647.25 g/mol
Purity: Batch-specific
Form: Lyophilized powder
Enquiry Sizes: Research vial • Bulk / custom fill (quote required)
Peptide Sequence30 residues: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Nε-maleimidopropionyl)-NH2

Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.

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Overview

CJC-1295 with DAC (DAC:GRF) is a synthetic analogue of growth-hormone-releasing hormone built on the tetrasubstituted GRF(1-29) backbone ([D-Ala2, Gln8, Ala15, Leu27]) and extended at position 30 with an Nε-maleimidopropionyl-lysine "drug affinity complex" (DAC). In the primary literature the DAC group forms a covalent bond with serum albumin, which markedly extends the analogue’s circulating half-life relative to native GHRH(1-29). The names CJC-1295, CJC-1295 DAC, and CJC-1295 with DAC are synonyms for this DAC-bearing molecule.

As a research tool it is used to study sustained GHRH-receptor engagement and its downstream effects on pulsatile growth-hormone release and IGF-1 dynamics in preclinical models. Its distinguishing feature versus non-DAC GHRH analogues is the albumin-tethering chemistry, which lets investigators examine prolonged receptor stimulation without repeated dosing in animal systems. Clinical development was discontinued, so its behavior outside research models is not established pharmacology.

BioTech Pharma supplies CJC-1295 with DAC as a lyophilized powder for laboratory research use only. It is not a drug and is not intended for human or veterinary use. Lot-specific analytical documentation may be available and should be confirmed for the applicable material. Bulk and custom-fill quantities are available by quote.

Research Applications

GHRH-receptor signaling and desensitization studies
Albumin-binding (DAC) prodrug/conjugation chemistry
Pulsatile growth-hormone secretion models
IGF-1 axis dynamics research
Comparative GHRH-analogue half-life studies

Frequently Asked Questions

Scientific References

Analytical Data

Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:

HPLC purity result
LC-MS identity confirmation
Appearance
Net content

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Procurement Details

Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.

Storage & Handling

Lyophilized: store desiccated at −20 °C, protected from light. Reconstituted: keep at 2–8 °C and determine working-solution stability empirically per lot; the maleimide group is reactive toward thiols, so avoid thiol-containing diluents.

Related Compounds

CJC-1295 (No DAC) / Modified GRF(1-29)

Tetrasubstituted GRF(1-29) analogue without the albumin-binding DAC group — a shorter-acting GHRH research peptide.

Tesamorelin

Stabilized GHRH analog used in growth-hormone-axis research, engineered for resistance to enzymatic degradation.

Ipamorelin

Selective pentapeptide ghrelin-receptor agonist prized in GH-axis research for its clean receptor-selectivity profile.