CJC-1295 (No DAC) / Modified GRF(1-29)
Also known as: Modified GRF (1-29), Mod GRF (1-29), tetrasubstituted GRF (1-29), CJC-1295 without DAC
- Purity
- Batch-specific
- Form
- Lyophilized powder
- Enquiry Sizes
- Research vial • Bulk / custom fill (quote required)
- Peptide Sequence
- H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.
Configure Your Request
Documentation requests are reviewed against the records available for the applicable lot. Availability, methods, and values must be confirmed for the specific enquiry and are not promised in advance.
Form supplied: Lyophilized powder. Your selections are carried into the quote request automatically.
Overview
Modified GRF(1-29), commonly labeled "CJC-1295 without DAC," is a 29-amino-acid analogue of growth-hormone-releasing hormone carrying four substitutions on the sermorelin/GRF(1-29) backbone: D-Ala at position 2, Gln at 8, Ala at 15, and Leu at 27. The D-Ala2 substitution in particular is intended to resist dipeptidyl peptidase-4 cleavage. Unlike CJC-1295 with DAC, this molecule lacks the position-30 maleimidopropionyl-lysine, so it does not bind albumin and is comparatively short-acting.
In endocrine research it serves as a GHRH-receptor agonist tool for studying pulsatile growth-hormone release and GHRH-pathway signaling in cell and animal models, often in comparison with native GHRH(1-29) (sermorelin) and with the DAC-bearing analogue. The literature frequently and incorrectly equates "CJC-1295" with this no-DAC peptide; the exact backbone sequence is well defined, but reported molecular-formula and mass values differ across secondary sources, so those fields are omitted here pending a primary-source-confirmed value.
BioTech Pharma supplies this peptide as a lyophilized powder for laboratory research use only. It is not a drug and is not intended for human or veterinary use. Lot-specific analytical documentation may be available and should be confirmed for the applicable material. Bulk and custom-fill quantities are available by quote.
Research Applications
- GHRH-receptor agonist pharmacology
- Pulsatile growth-hormone secretion models
- DPP-4 resistance and peptide-stabilization chemistry
- Comparative GHRH-analogue studies (vs sermorelin and DAC form)
- GH/IGF-1 axis signaling research
Frequently Asked Questions
Scientific References
Analytical Data
Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:
- HPLC purity result
- LC-MS identity confirmation
- Appearance
- Net content
Request the records you need with your quote and we will confirm availability for your batch.
Procurement Details
Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.
Storage & Handling
Lyophilized: store desiccated at −20 °C, protected from light. Reconstituted: keep at 2–8 °C and establish working-solution stability empirically per lot, as prepared-solution stability depends on diluent, concentration, and handling.
Related Compounds
CJC-1295 with DAC
Long-acting GHRH analogue bearing a maleimidopropionyl-lysine drug-affinity complex that binds albumin, studied in GH-axis research.
Tesamorelin
Stabilized GHRH analog used in growth-hormone-axis research, engineered for resistance to enzymatic degradation.
Ipamorelin
Selective pentapeptide ghrelin-receptor agonist prized in GH-axis research for its clean receptor-selectivity profile.