2D Molecular Structure
- CID
- 16154396
- Standard InChIKey
- UAHFGYDRQSXQEB-LEBBXHLNSA-N
- FDA UNII
- QW68W3J66U
- Residue Count
- 13 AA
- Structural Modifications
- N-terminal acetyl
- C-terminal amide
- [Nle4, D-Phe7] substitutions
Afamelanotide
Also known as: Melanotan I, Melanotan-1, [Nle4,D-Phe7]-α-MSH, NDP-MSH
- CAS Number
- 75921-69-6
- Molecular Formula
- C78H111N21O19
- Molecular Weight
- 1646.8 g/mol
- Purity
- Batch-specific
- Form
- Lyophilized powder
- Enquiry Sizes
- Research vial • Bulk / custom fill (quote required)
- Peptide Sequence13 residues
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Compliance Notice: All products supplied by BioTech Pharma are intended strictly for laboratory research and development use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption of any kind. By submitting an enquiry, the requester confirms they are a qualified researcher or institution and accepts full responsibility for compliant handling and use.
Configure Your Request
Documentation requests are reviewed against the records available for the applicable lot. Availability, methods, and values must be confirmed for the specific enquiry and are not promised in advance.
Form supplied: Lyophilized powder. Your selections are carried into the quote request automatically.
Overview
Afamelanotide (also called Melanotan I or NDP-MSH) is a linear tridecapeptide analog of α-MSH carrying norleucine at position 4 and D-phenylalanine at position 7. These substitutions markedly increase potency and metabolic stability relative to native α-MSH, making it one of the most extensively characterized melanocortin agonists in the literature.
As an established pharmacology, afamelanotide is a regulator-recognized active ingredient: it is the drug substance in an approved product for a specific inherited photosensitivity disorder. In a research setting it serves as a stable, high-affinity melanocortin reference compound for melanogenesis, MC1R signaling, and photoprotection studies — distinct from its clinical role, which BioTech Pharma does not address.
BioTech Pharma supplies afamelanotide as a lyophilized powder for in-vitro and preclinical research use only. It is not supplied for human, clinical, or veterinary use. Lot-specific analytical documentation may be available and should be confirmed for the applicable material.
Research Applications
- MC1R signaling and melanogenesis models
- Eumelanin synthesis in melanocyte culture
- UV-photoprotection mechanism studies (in vitro)
- Comparative melanocortin-agonist pharmacology
Frequently Asked Questions
Scientific References
Analytical Data
Lot-specific documentation may be available for the applicable material and must be confirmed per enquiry. Where available, it may include:
- HPLC purity result
- LC-MS identity confirmation
- Appearance
- Net content
Request the records you need with your quote and we will confirm availability for your batch.
Procurement Details
Availability, lead time, salt / content basis, and cold-chain requirements depend on the specific lot and quantity, so we confirm them per enquiry rather than publishing fixed figures. Request confirmation for your requirements with your quote and our team will respond with details for the applicable batch.
Storage & Handling
Lyophilized: store at −20 °C, protected from light and moisture. Reconstituted: store cold and protected from light; verify prepared-solution stability for the applicable material before extended use.
Related Compounds
Melanotan II
Cyclic synthetic melanocortin-receptor agonist analog of α-MSH, used as a reference tool in melanocortin-pathway research.
GHK-Cu
Naturally occurring copper tripeptide complex, central to dermal-matrix, collagen-synthesis, and cosmetic-formulation research.
Bacteriostatic Water
Aqueous laboratory research reagent studied as a companion diluent for reconstituting lyophilized peptides in the laboratory.